Henry Long desperately seeks a cure for the condition that leaves him unable to feel physical pain.

When a film crew moves into an abandoned psychiatric hospital with a shadowy past to shoot a low budget horror film, they get more than they bargained for. The late nights and lack of sleep begin to take a toll, and the longer this crew works, the more the leaky, wet building seems to be coming back to life, feeding off its new inhabitants. As the shoot wears on, members of the crew exhibit increasingly strange behavior leaving those still sane realizing they need to get out of this place before they too succumb to the building's infectious hold, the only problem, the old hospital is not ready to let them go.

A freak accident turns a bulk of the world's population into lethal flesh-eating zombies. A small and desperate group of uninfected human survivors take refuge in a vacant casino in Reno, Nevada. Meanwhile, the undead outside become smarter, stronger, and more aggressive with each passing day.